Dendrimers are known for their three dimensional, monodispersed, highly branched, macromolecular nano-scopic architecture with number of reactive end groups. Dendrimers have been reported to act as solubilizing agents to host both hydrophilic and hydrophobic drugs. The present study was performed to investigate the effect of poly (propylene) imine dendrimers (5.0G) mediated solubility enhancements of hydrophobe. The solubility of prednisolone was enhanced at pH 7.4. The drug-dendrimer complex followed 1:1 stoichiometry (AL type of curve) and was characterized for stability of complex and thermodynamic properties. Thermodynamic properties were utilized to elucidate the mechanism behind dendrimer mediated solubility enhancement. The data suggested that hydrophobic and electrostatic interactions were responsible for solubility enhancement. Conclusively, PPI dendrimers were found useful in solubility enhancement of prednisolone and their solubilization ability was clearly regulated by pH and chemical nature of the drug.
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